ORMDL3. Does that mean anything to you? Perhaps only a set of letters and a figure. That’s all. Idem for me too. Not for scientists though. It seems to be the culprit. It’s a gene found in a more significant amount in the blood cells of children with asthma than in those without. This higher level of ORMDL3 could increase the risk of having asthma by about 70%.
That’s what a group of researchers from Imperial College London, along with others from UK, France, Germany, USA and Austria, have concluded after a study carried out on more than 2000 children.
Childhood asthma is a common chronic disease. 10% of children in the UK are currently affected. It’s a tough time indeed, for the children as it is for the parents. Therapies have hitherto been limited to attenuating the episodes of asthma, without significant progress into its cure.
Deep probe has yet to be effected into the exact causes of asthma. It is not well understood how ORMLD3 exacerbates the risk of asthmatic conditions in children. But the combination of genetic and environmental factors provides a definite clue.
The researchers compared the genetic makeup of childhood asthmatic and non-asthmatic patients. They probed into the mutational behavior of the nucleotides, the building blocks of genes making up the DNA (Deoxyribonucleic acid – a self-replicating material present in nearly all living organisms carrying the genetic information). Mutations were observed and the researchers unveiled those specific to childhood asthma.
The new findings will, it is hoped, pave the way for the development of new therapies. For further information see links below: